Summary:This session, led by Dr Susie Hiniker (Associate Professor, Stanford University, specialising in paediatric and CNS cancers), provides a comprehensive, practice-oriented overview of glioma management in both adult and paediatric populations. Participants explore the evolving classification of gliomas, differences in tumour biology between age groups, and how these factors shape risk stratification and treatment strategies.
Key topics include:
-
Current WHO glioma classifications and the shift from histology-based to molecularly driven diagnosis.
-
Low-grade glioma management:
-
Variations in adult vs paediatric approaches.
-
Surgical goals, chemotherapy, targeted therapies (MEK/BRAF inhibitors), and the role of radiotherapy.
-
Margin definitions, dose prescriptions, and contouring considerations.
-
Special considerations for NF1 patients and strategies to delay radiation in children.
-
High-grade glioma treatment paradigms:
-
Standard-of-care approaches in adults (Stupp protocol) and adaptations for paediatrics.
-
Hypofractionated schedules, concurrent and adjuvant therapies, and tumour treating fields.
-
Re-irradiation strategies and fractionation options.
-
Contouring principles:
-
GTV/CTV delineation using MRI sequences (T1, T2, FLAIR) to differentiate tumour from oedema.
-
Anatomical barriers to spread, common pitfalls, and margin adjustments.
-
Diffuse midline glioma (DMG/DIPG):
-
Modern diagnostic and biopsy practices.
-
Standard fractionation vs hypofractionation.
-
Emerging clinical trials, including CAR T-cell therapy and concurrent tumour treating fields.
Through case discussions, imaging reviews, and contouring exercises, this session delivers practical guidance for applying evidence-based radiotherapy techniques to optimise tumour control while minimising toxicity.
- Duration: 60 min
- Language: English
- Country: UK
- Level: Basic
Keywords:
